Fluticasone
Brand names: Flovent (inhaler), Flonase (nasal), Arnuity
Class: 🫁 Asthma/COPD Medications
When a vignette puts you on a controller inhaler, fluticasone is the prototype inhaled corticosteroid. It reduces airway inflammation and is the backbone of step-2 and beyond asthma therapy in both children and adults; it also reduces COPD exacerbations in moderate-to-severe disease, particularly with eosinophilia. The intranasal form (Flonase) is first-line for allergic rhinitis and the topical form treats eczema. The board counseling points are universal: rinse mouth or use a spacer to prevent oral candidiasis and dysphonia, expect onset over weeks (not minutes), and never use ICS as rescue. ICS plus LABA is the next step up; LABA monotherapy in asthma carries a black box.
✅ Indications
Persistent asthma (controller), allergic rhinitis (nasal), eczema (topical).
⚙️ Mechanism of Action
Inhaled corticosteroid — anti-inflammatory via genomic corticosteroid effects.
📏 Dosing
Inhaler: low/mid/high dose (e.g., Flovent 88/220 mcg BID). Nasal: 1–2 sprays each nostril daily.
🚫 Contraindications
Untreated fungal/bacterial/TB infection of airway.
⚠️ Adverse Effects
Oral thrush (candidiasis), dysphonia (hoarseness), adrenal suppression at high dose, ↓ growth velocity (kids — usually catches up).
🔬 Monitoring
Growth in kids (though long-term effect minimal), symptom control.
💎 Board Pearls
- 💧 RINSE MOUTH after use → prevents oral thrush.
- 🎯 Use SPACER with MDI → better delivery, less oropharyngeal deposition.
- 👶 ICS safe in kids — ↓ growth velocity minimal; uncontrolled asthma worse.
- 🏆 ICS = MAINSTAY of persistent asthma control.
Practice Questions
An adult patient with persistent asthma has been prescribed fluticasone (Flovent) HFA inhaler twice daily. Which instruction should the nurse practitioner emphasize for every use?
Related Drugs in This Class
- Albuterol — Proventil, ProAir, Ventolin
- Tiotropium — Spiriva
- Montelukast — Singulair
Sources
Ready to practice?
1,500+ AANP-style questions with rationales — free trial.